Adaptive clinical trial software
In May 2000 I joined the Department of Biostatistics at MD Anderson Cancer Center to build and lead its software development group, starting with three developers and growing the team to around 20 at its height. We developed the infrastructure for designing and conducting adaptive clinical trials based on Bayesian methods.
In addition to leading the software development group, I developed the C++ numerical library at the heart of our software and developed algorithms for several of the most commonly used applications.
Working at MD Anderson, the world’s largest cancer center, gave me the opportunity to be involved with many clinical trials in roles ranging from initial design and simulation to conduct, support, and analysis.
In addition to my work at MD Anderson, I have consulted for pharmaceutical companies regarding adaptive clinical trial design and conduct.
I have taught short courses in Bayesian clinical trial software at L’Institut Bergonié in Bordeaux and at University of Puerto Rico in San Juan. I have also given shorter presentations on clinical trial software at Vanderbilt University and University of Houston.
Some of the clinical trial software I have contributed to is available here.
My publications include papers on Bayesian analysis and numerical algorithm design for Bayesian computation.